Researchers have been burning midnight oil since the end of 2018 to reach the core of the current pandemic, Covid-19. Several vaccines have been developed while some are still in the works in different parts of the world. To save humanity, some scientists have reached milestones in the search for breakthroughs in HIV and AIDS. In the past three months, scientists have made three major breakthroughs in saving humanity from HIV and AIDS, which affect more than 38 million people worldwide. In seven African countries, women given long-term injections of cabotegravir were found to have 89% more HIV infections than women prescribed daily Prep. The research was led by Professor Sinead Delany-Moretlwe of the Witwatersrand University in South Africa. HIV oral pills are effective, but daily pill adherence has proven problematic for patients grappling with endless prejudices. Injecting PrEP will help reduce the risk of HIV infection and AIDS, especially during periods of high prevalence.The injection is given once a month, so it is useful for people who face daily discrimination based on their status, sex workers, and mismatched partners. Without these prevention options in the study communities, the HIV incidence is around 3.5% per person year. The oral PrEP group in the study was 1.9% and the injectable PrEP group was 0.2%. Monthly Injections for HIV Patients, the U.S Food and Drug Administration (FDA) approved an injectable drug called Cabenuva, which consists of cabotegravir and rilpivirine. ViiV Healthcare, for the treatment of HIV infection in adults. The Cabenuva injection is intended to replace the daily antiretroviral regimen used by HIV-infected adults.Cabenuva combines cabotegravir, an HIV integrase strand transfer inhibitor, and rilpivirine, an HIV non-nucleoside reverse transcriptase inhibitor. A study of 1,100 patients from 16 countries in 48 weeks found the drug to be effective in suppressing HIV, helps those who struggle to carry their medication, as well as those who face the daily stigma associated with the disease. The injection has mild side effects and those tested reported mild symptoms such as headache, fatigue, trouble sleeping, dizziness, rash, and pyrexia. Vaginal ring for decades, practicing safe sex has always been the best way to protect people from HIV infection and AIDS, especially among women and girls. Today women represent more than half of the people affected by HIV and AIDS worldwide. The study, carried out a few months ago, found that 60% of people infected with HIV and AIDS in sub-Saharan Africa are women. A Custom Made Vaginal Ring for Women Known As Dapivirine Vaginal Ring (DPV-VR) has been in the market for quite a while and has helped caution women from HIV infection. The ring has been shown to be effective in reducing the risk of HIV by 35%. Recent data from open-label extension studies suggest a further reduction in HIV risk by about half.